Representative Darrio Melton was born and raised in historic Selma, Alabama, where he graduated from Selma public schools before attending college at the University of Alabama at Birmingham. Upon completing his undergraduate work in Birmingham, graduating cum laude and with University Honors, he obtained his Masters in Divinity from Emory University in Atlanta, Georgia.

Because of his passion for rural community building, he returned home to Selma with his wife, Christi (Amory), to raise their two children, Darrio II and Kinslee Joi. He began serving as the associate pastor at Tabernacle of Praise Church and working as an adjunct professor at Wallace State Community College. He also served as a staffer in Congressman Artur Davis's office, which led him to pursue a career in public service.

In 2010, Melton ran for the Alabama House of Representatives in district 67 and was elected to serve in the Alabama Legislature. Despite being one of the youngest members of the House, he was recognized in 2011 as the Freshman Legislator of the Year by his fellow legislators. He was also named Legislator of the Year by the House Democratic Caucus during that same year.

While Democrats are at a disadvantage in the Alabama Legislature, Melton has been able to secure some notable legislative victories, including saving $100,000 for the Black Belt Treasures program, which provides vital funding for the arts and economic development across the Black Belt. Melton has also been named one of the "Top 20 Under 40" in Black Alabama.

In 2014, he was re-elected without opposition to the Alabama House of Representatives. Shortly after, he was elected to lead his fellow Democrats as the Chair of the House Democratic Caucus, where he will work to push Democrats' legislative agenda on the House floor for the next four years.